Antibodies to MHC class I induce autoimmunity: role in the pathogenesis of chronic rejection.

Chronic Rejection Autoimmunity: Role in the Pathogenesis of Antibodies to MHC Class I Induce and Thalachallour Mohanakumar

Antibodies to MHC Class II Molecules Induce Autoimmunity: Critical Role for Macrophages in the Immunopathogenesis of Obliterative Airway Disease

Previous studies have shown that intrabronchial administration of antibodies (Abs) to MHC class I resulted in development of obliterative airway disease (OAD), a correlate of chronic human lung allograft rejection. Since development of Abs specific to mismatched donor HLA class II have also been associated with chronic human lung allograft rejection, we analyzed the role of Abs to MHC class II ...

پیشرفت های جدید در شناخت اسپوندیلوآرتروپاتی ها

In last few years, numerous observations and studies on pathogenesis of spondyloarthropathies have been published and an animal model which confirms the associations of new information is now available. Bacteria which are responsible for reactive arthritis all can remain in the cells for long time. Molecules of class I MHC are able to present the intracellular peptides to immune system. B27 mol...

Alloimmunity induced autoimmunity: Role in the pathogenesis of chronic allograft rejection

Tremendous progress has been made in the field of transplantation with significant improvement in preventing acute rejection that has resulted in improved graft survival. However long term graft survival still remains limited due to chronic allograft rejection. Chronic rejection is a major impediment for long-term graft function and its incidence is almost universal especially following human l...

Role of antibodies to self-antigens in chronic allograft rejection: potential mechanism and therapeutic implications.

Significant progress has been made in preventing acute allograft rejection following solid organ transplantation resulting in improved allograft survival. However, long term function still remains disappointing primarily due to chronic allograft rejection. Alloimmune responses primarily defined by the development of antibodies (Abs) to donor mismatched major histocompatibility antigens during t...